|
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Wrist circumference, a marker of insulin resistance, is associated with increased SBP in overweight/obese children and adolescents, suggesting a role of insulin resistance in the pathogenesis and development of hypertension.
|
29335612 |
2018 |
|
Hyperandrogenism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Women with NC-CAH had significantly lower orgasm scores, a trend toward lower sexual function with higher sexual distress, as well as biochemical evidence of hyperandrogenism (higher dehydroepiandrosterone sulfate and lower SHBG) and a trend toward more clinical signs of hyperandrogenism (hirsutism).
|
31447379 |
2019 |
|
Polycystic Ovary Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Women with PCOS-AH had lower SHBG (29.2 ± 13.8 vs 32.4 ± 11.8 nmol/L, <i>P</i> = 0.025) and higher TT (1.0 ± 0.2 vs 0.8 ± 0.4 ng/mL, <i>P</i> = 0.05) and Δ4A (3.9 ± 1.2 vs 3.4 ± 1.0 ng/mL, <i>P</i> = 0.007) concentrations, as well as FAI (14.1 ± 8.0 vs 10.2 ± 5.0, <i>P</i> < 0.001).
|
28912337 |
2017 |
|
Polycystic Ovary Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Women with PCOS presented with higher body-mass index, insulin resistance, T, FT, A, and ACTH-stimulated 17-OHP serum concentrations and lower SHBG serum levels, as compared with controls.
|
11334920 |
2001 |
|
Left Ventricular Hypertrophy
|
0.070 |
Biomarker
|
disease |
BEFREE |
With stepwise adjusted for potential covariates including age, male gender, fasting plasma glucose, presence of current cigarette smoking, dyslipidemia, statins and SBP, increased cf-PWV remained independently associated with left ventricular hypertrophy and albuminuria, with an increased odds of 41 % and 24 % (<i>p</i> < 0.05), respectively.
|
30393492 |
2018 |
|
Barrett Esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
While plasma hormone and sex hormone-binding globulin concentrations were not associated with all cases of Barrett's esophagus, we did observe positive associations with estrogens in younger men (e.g. estrone + estradiol OR<sub>continuous per ½</sub><sub>IQR</sub><sub> </sub> = 2.92, 95%CI:1.08, 7.89), and free androgens in men with higher waist-to-hip ratios (e.g. free testosterone OR<sub>continuous per ½</sub><sub>IQR</sub><sub> </sub> = 2.71, 95%CI:1.06, 6.92).
|
28241109 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
While low circulating total testosterone concentrations in modest obesity primarily reflect reduced concentrations of sex hormone binding globulin, more marked obesity can lead to genuine hypothalamic-pituitary-testicular axis (HPT) suppression.
|
29683196 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Whether SBP VVV is also a predictor of CKD development in diabetes is currently uncertain.
|
30817462 |
2019 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Whether SBP VVV is also a predictor of CKD development in diabetes is currently uncertain.
|
30817462 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Whether SBP VVV is also a predictor of CKD development in diabetes is currently uncertain.
|
30624364 |
2019 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Whether SBP VVV is also a predictor of CKD development in diabetes is currently uncertain.
|
30624364 |
2019 |
|
Major Depressive Disorder
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Whereas SHBG levels did not differ between the depressed/nondepressed groups (F(1,149) = 0.075, p = 0.78), men with MDD had lower mean total and free testosterone levels than the comparison group in the multivariate adjusted analyses (F(1,150) = 7.249, p = 0.008, Cohen's d = 0.51; and F(1,149) = 8.548, p = 0.004 Cohen's d = 0.55, respectively).
|
28132748 |
2017 |
|
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
When stratified by the hypertension medication status, interaction effect was found only in individuals taking medication (P-interaction = 0.004 for SBP and 0.001 for DBP).
|
25304467 |
2015 |
|
Malignant neoplasm of breast
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
When all studies were pooled into the meta-analysis, there was no evidence for significant association between SHBG Asp327Asn polymorphism and breast cancer risk (for Asn/Asn vs. Asp/Asp: OR = 1.20, 95 % CI = 0.94-1.55; for Asp/Asn vs. Asp/Asp: OR = 0.94, 95 % CI = 0.87-1.01; for dominant model: OR = 0.95, 95 % CI = 0.90-1.02; for recessive model: OR = 1.22, 95 % CI = 0.95-1.57).
|
22711300 |
2012 |
|
Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
When all studies were pooled into the meta-analysis, there was no evidence for significant association between SHBG Asp327Asn polymorphism and breast cancer risk (for Asn/Asn vs. Asp/Asp: OR = 1.20, 95 % CI = 0.94-1.55; for Asp/Asn vs. Asp/Asp: OR = 0.94, 95 % CI = 0.87-1.01; for dominant model: OR = 0.95, 95 % CI = 0.90-1.02; for recessive model: OR = 1.22, 95 % CI = 0.95-1.57).
|
22711300 |
2012 |
|
Hyperinsulinism
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Weight reduction not only increased insulin sensitivity but also elevated serum SHBG levels in obese adults and children.
|
28489766 |
2017 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We used inverse variance weighting (IVW) to assess the relation of HbA1c with risk of hypertension (defined using the American College of Cardiology/American Heart Association 2017 guidelines), and SBP and DBP.
|
31386636 |
2020 |
|
Cardiovascular Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
We used cross-sectional data from 2913 men aged 76.7 ± 3.2 years with morning blood samples assayed for T, DHT, E2 (mass spectrometry), and sex hormone-binding globulin (SHBG, immunoassay), to correlate sex hormones with LTL measured using PCR and expressed as T/S ratio in multivariable linear regression models adjusted for age, cardiometabolic risk factors and cardiovascular disease history.
|
30561819 |
2019 |
|
Clubbed Fingers
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We therefore measured estrogens, androgens, sex hormone-binding globulin (SHBG), and gonadotropins in five patients with HOA and in 18 patients with simple clubbing.
|
29480386 |
2019 |
|
Clubbing
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
We therefore measured estrogens, androgens, sex hormone-binding globulin (SHBG), and gonadotropins in five patients with HOA and in 18 patients with simple clubbing.
|
29480386 |
2019 |
|
Osteoarthritis of the hand
|
0.010 |
Biomarker
|
disease |
BEFREE |
We therefore measured estrogens, androgens, sex hormone-binding globulin (SHBG), and gonadotropins in five patients with HOA and in 18 patients with simple clubbing.
|
29480386 |
2019 |
|
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
We therefore designed a dose-finding study to assess the effects of 1, 2 and 5 g NWT-03 on daytime, 36-h, and night-time systolic and diastolic BP (SBP and DBP) in ninety-two generally healthy subjects with normal BP (n 29), high-normal BP (n 34) or mild hypertension (n 29).
|
28485264 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.400 |
Biomarker
|
disease |
BEFREE |
We tested the hypothesis that the appropriate home morning SBP cutoff value is 125 mmHg in our stratification of cardiovascular risk in type 2 diabetes.
|
29369147 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
We tested the effects of weight loss on serum estradiol, estrone, testosterone, and sex hormone-binding globulin (SHBG) in overweight/obese women 18 months after completing a year-long, 4-arm, randomized-controlled dietary weight loss and/or exercise trial.
|
30461557 |
2019 |
|
Polycystic Ovary Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
We studied the effects of the SHBG (TAAAA)(n) and androgen receptor gene [AR] (CAG)(n) allele length on endocrine-metabolic features and body composition (by dual-energy X-ray absorptiometry) before and after 1 year on metformin (850 mg/d) in 70 girls with polycystic ovary syndrome after precocious pubarche; allele lengths were assessed by polymerase chain reaction in both patients and in population control subjects (n = 107).
|
20691435 |
2010 |